METHOD FOR DISCRIMINATING SENSITIZING EFFECT OF HYPOXIC CELL SENSITIZER AND APOPTOSIS SIGNAL HOLDING AGENT UNDER HYPOXIC CONDITION

摘要

PROBLEM TO BE SOLVED: To provide a simple method for discriminating sensitizing effects of a hypoxic cell radiosensitizer in vitro with which the stability is excellent. SOLUTION: The method for discriminating the sensitizing effects of the hypoxic cell radiosensitizer is used for a radiotherapy of radiation-resistant cancer. In the method, the degree of apoptosis and/or an apoptosis signal in the presence and absence of the hypoxic cell radiosensitizer is used as an index for cancer cells under hypoxic conditions and the cancer cells under aerobic conditions. COPYRIGHT: (C)2005,JPO&NCIPI