MODIFIED FIBER PROTEINS FOR EFFICIENT RECEPTOR BINDING
摘要
Recombinant detargeted and retargeted adenovirus viral particles and vectors are provided. In particular, modified fibers from adenoviruses that bind to coxsackie-adenovirus receptor (CAR) in vivo that contain modifications in the fiber shaft are provided. Adenovirus (Ad) particles that express such fibers exhibit reduced binding to CAR. Hence detargeted Ad particles are provides; also provided are retargeted particles.
申请公布号
WO2004111251(A9)
申请公布日期
2005.02.03
申请号
WO2004US18623
申请日期
2004.06.10
申请人
THE SCRIPPS RESEARCH INSTITUTE;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;NEMEROW, GLEN, R.;WU, EUGENE;STEWART, PHOEBE