发明名称 |
Medical device with coating for capturing genetically-altered cells and methods for using same |
摘要 |
Therapeutic and drug delivery systems are provided in the form of medical devices with coatings for capturing and immobilizing target cells such as circulating progenitor or genetically-altered mammalian cells in vivo. The genetically-altered cells are transfected with genetic material for expressing a marker gene and a therapeutic gene in a constitutively or controlled manner. The marker gene is a cell membrane antigen not found in circulating cells in the blood stream and therapeutic gene encodes a peptide for the treatment of disease, such as, vascular disease and cancer. The coating on the medical device may be a biocompatible matrix comprising at least one type of ligand, such as antibodies, antibody fragments, other peptides and small molecules, which recognize and bind the target cells. The therapeutic and/or drug delivery systems may be provided with a signal source such as activator molecules for stimulating the modified cells to express and secrete the desired marker and therapeutic gene products.
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申请公布号 |
US2005025752(A1) |
申请公布日期 |
2005.02.03 |
申请号 |
US20040835767 |
申请日期 |
2004.04.30 |
申请人 |
KUTRYK MICHAEL J. B.;COTTONE ROBERT J.;ROWLAND STEPHEN M. |
发明人 |
KUTRYK MICHAEL J. B.;COTTONE ROBERT J.;ROWLAND STEPHEN M. |
分类号 |
A61L27/08;A61L27/30;A61L27/44;A61L27/54;A61L29/10;A61L29/12;A61L29/16;A61L31/08;A61L31/12;A61L31/16;C12N5/08;(IPC1-7):A61K48/00;C12N15/85 |
主分类号 |
A61L27/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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