| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a production method for a catalyst used for producing, in large quantities, an optically active α-aminophosphonic acid derivative using small quantities of an optically active raw material by a simple operation of few steps. <P>SOLUTION: The catalyst for an asymmetric synthesis shown by the formula (A):La-X-binaphthol complex (in the formula, X is an alkali metal ) is produced by reacting, under nitrogen atmosphere and in a nonaqueous solvent or an aqueous solvent, (R)-2,2'-dihydroxy-1,1'-binaphthyl or (S)-2,2'-dihydroxy-1,1'-binaphthyl, a lanthanalkoxide shown by the formula (VI):La(OR)<SB>3</SB>(R is an alkyl group) and one kind of alkali metal compound selected from (VII), (VIII) and (IX) expressed below, wherein the above (VII) is a compound expressed by LiA (A is an alkyl group), (VIII) is a compound expressed by ((CH<SB>3</SB>)<SB>3</SB>Si)<SB>2</SB>NK and (IX) is ZOR (Z is an alkali metal and R is an alkyl group). <P>COPYRIGHT: (C)2005,JPO&NCIPI |
