摘要 |
<p>Psychotropic agents, partic. antidepressents, contain as active ingredients cpds. (I) 1,10-trimethylene-8-methyl-1,2,3,4-tetrahydropyrazino- 1,2-a -ind- ole. HCl salt of (I) can be prepd. by alkylation in presence of base of 1-keto-1,2,3,4-tetrahydro-6-methyl-carbazole (II) which chloroacetonitrile to form 1-keto-1,2,3,4-tetrahydro-6-methyl-9-cyanomethylcarbazole (III) which upon reductive cyclisation by hydrogenation yields (I).</p> |
申请人 |
VSESOJUZNY NAUCHNO-ISSLEDOVATELSKY KHIMIKO-FARMATSEVTICHESKY INSTITUT IMENI SERGO ORDZHONIKIDZE, ZUBOVSKAYA ULITSA 7, MOSCOU, (U.R.S.S.), |
发明人 |
M.D. MASHKOVSKY;A.N. GRINEV;V.I. SHVEDOV;N.I. ANDREEVA;L.B. ALTUKHOVA |