| 摘要 |
Provided are antibacterial compounds having Formula I:In such compositions, X is O or S; Y is CH2; n is 0 or 1. One of R1 and R1' is -C(O)NR5R5', -C(O)-Q-NR5R5', -CH2NR5R5' or -S(O)2NR5R5' and the other is H or R3. One of R2 and R2' is -NHC(O)R6 or -NHS(O)2R6 and the other is H or R4. Q is an amino acid or peptide. R3 is H, halogen, -NR5R5' or -NHC(O)R6; and R4 is selected from the group consisting of H, halogen, hydroxyl, amino, carboxyl, alkyl, alkenyl and alkynyl. R5 is selected from the group consisting of H, alkyl, alkenyl or alkynyl optionally substituted with halogen, OH, amino, amidinyl, guanidinyl, urea, alkyl, carboxyl, oxo, carboxamide; R5' is H or R5 and R5' together form a 5-16 member heterocycle optionally substituted with halogen, OH, amino, alkyl, carboxyl, carbonyl or carboxamide. R6 is selected from the group consisting of H; amino; alkyl, alkenyl or alkynyl, each optionally substituted with halogen, amino, amidinyl, guanidinyl, urea, carboxyl or carboxamide; a 5-16 member carbocycle or heterocycle; and a 5-16 member heterocycle-substituted alkyl or carbocycle-substituted alkyl, wherein said carbocycle and heterocycle are optionally substituted with halogen, OH, amino, alkyl, carboxyl, oxo or carboxamide.
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