| 摘要 |
A compound selected from those of formula (I):in which:W represents N or C-R1; in which R1 is as defined in the description,X represents N or C-R2 in which R2 is as defined in the description,Y represents a group selected from oxygen, sulfur, -NH, and -Nalkyl,Z represents a group selected from oxygen, sulphur, -NR8 in which R8 is as defined in the description, and optionally carbon depending the definition of Y,n is an integer from 0 to 8 inclusive,Z1 represents a group -CR9R10 wherein R9 and R10, are as defined in the description, which group contains optionally multiple bonds or heteroatomes,A represents a cyclic group,m is an integer from 0 to 7 inclusive,the group(s) R4 is (are) as defined in the description,R3 represents a group selected from hydrogen, alkyl, alkenyl, alkynyl, and the group of formula:in which p, Z2, B, q, and R13 are as defined in the description,optionally, its racemic forms, isomers thereof, N-oxydes thereof, and its the pharmaceutically acceptable salts thereof, and medicinal products containing the same are useful as specific inhibitors of type-13 matrix mettaloprotease.
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