| 发明名称 |
Oligonucleotide modulation of cell adhesion |
| 摘要 |
Compositions and methods for the treatment of ophthalmic disorders, particularly preservation of corneal explants and prevention of corneal allograft rejection. These compositions comprise oligonucleotides which are specifically hybridizable with nucleic acids encoding the cellular adhesion molecules intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and endothelial leukocyte adhesion molecule-1 (ELAM-1).
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| 申请公布号 |
US6849612(B2) |
申请公布日期 |
2005.02.01 |
| 申请号 |
US20010982262 |
申请日期 |
2001.10.18 |
| 申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
BENNETT C. FRANK;MIRABELLI CHRISTOPHER |
| 分类号 |
A01N1/02;A01N43/04;A61K38/00;A61K48/00;A61P1/16;A61P27/02;A61P29/00;A61P31/00;A61P31/14;A61P31/18;A61P35/00;A61P43/00;C07H21/02;C07H21/04;C12N5/22;C12N15/113;C12N15/12;C12N15/63;C12P19/34;(IPC1-7):A01N43/04 |
主分类号 |
A01N1/02 |
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