Delayed-release pharmaceutical formulations

摘要

A delayed-release pharmaceutical formulation containing proinsulin C-peptide, which is present in an absorbable matrix comprising absorbable polymers wherein the matrix comprised one or more polymers with glycolide and/or lactide units and wherein the matrix is obtainable by mixing the lactide and/or glycolide units in the presence of tin (II) catalyst and/or an electrolyte containing polyol which acts a s a moderator without being incorporated in the polyester or bound thereto in any substantial amount, under conditions which allow polymerization thereof; and the use of the formulation for the manufacture of a medicament for treating diabetes or complications of diabetes or for shortening the electrocardiographic QT interval or for treating diabetic neuropathy, diabetic nephthropathy or diabetic retinopathy.