COMPLEJO PROMOTOR BI-DIRECCIONAL QUE COMPRENDE UNA REGION AMPLIFICADORA MODIFICADA CON AL MENOS DOS REGIONES AMPLIFICADORAS Y POR LO MENOS DOS PROMOTORES BASICOS; VECTOR QUE COMPRENDE DICHO COMPLEJO; CELULAR TRANSFECTADA CON DICHO VECTOR Y METODO PAR

摘要

The present invention is directed to bidirectional promoter complexes that are effective for enhancing transcriptional activity of transgenes. The bidirectional promoters of the invention include a modified enhancer region with at least two core promoters on either side of the modified enhancer in a divergent orientation.