发明名称 |
New beta crystalline form of perindopril tert-butylamine salt, a process for its preparation and pharmaceutical compositions containing it |
摘要 |
Disclosed is a beta crystalline form of the compound of Formula (I). Also disclosed are processes of making such crystalline forms characterised in that a solution of perindopril tert-butylamine salt in dichloromethane is heated at reflux, the solution is then cooled to 0 degrees C and the solid obtained is collected by filtration. Alternatively, the solvent may be ethyl acetate, in which case it is cooled rapidly to 5 degrees C and the resulting solid collected by filtration. |
申请公布号 |
NZ523234(A) |
申请公布日期 |
2005.01.28 |
申请号 |
NZ20010523234 |
申请日期 |
2001.07.06 |
申请人 |
LES LABORATOIRES SERVIER |
发明人 |
GINOT, YVES-MICHEL;COQUEREL, GERARD;BEILLES, STEPHANE;PFEIFFER, BRUNO |
分类号 |
A61K9/20;A61K31/404;A61K38/00;A61K38/55;A61K45/00;A61P7/10;A61P9/00;A61P9/04;A61P9/10;A61P9/12;A61P13/02;A61P43/00;B01D9/02;C07D209/42;C07K1/30;C07K5/062 |
主分类号 |
A61K9/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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