New peptide that inhibits translation of protein, useful as part of a control system for e.g. protein production in bioreactors or somatic gene therapy, and treatment of cancer

摘要

Peptide (I) that inhibits translation of proteins, contains at most 250 amino acids (aa) and including a sequence at least 85% identical with sequence (S1), is new. Peptide (I) that inhibits translation of proteins, contains at most 250 amino acids (aa) and including a sequence at least 85% identical with sequence (S1), is new Val-Lys-Phe-Ala-Asp-Thr-Gln-Lys-Asp-Lys-Glu-Gln-Lys-Arg-Met-Thr-Gln-Gln-Leu-(Gln) 3-Met-Gln-Gln-Leu-Asn-Ala (S1). Independent claims are also included for the following: (1) fusion protein (FP) that inhibits specifically translation of a target polynucleotide (T) comprising (I) fused to an RNA-binding protein (II); (2) nucleic acid (III) that encodes (I); (3) nucleic acid (IIIa) that encodes FP; (4) system for controlling translation of (T) comprising FP or (IIIa); (5) recombinant cloning or expression vectors that contain (III) or (IIIa); (6) prokaryotic or eukaryotic host cells that contain a system of (4), (IIIa) or a vector containing (IIIa); (7) method for in vitro control of translation of (T); and (8) kit for controlling translation of (T) that comprises FP or a vector that contains (IIIa). ACTIVITY : Virucide; Cytostatic. No details of tests for these activities are given. MECHANISM OF ACTION : Inhibition of protein translation; Gene Therapy.