Method to prepare microparticles metoprolol that contain

摘要

A method of preparing a homogeneous microparticle of metoprolol the method comprising: providing a granulation liquid medium comprising a solid content of metoprolol; spraying the granulation liquid medium into a fluidized bed; and selecting out a microparticle that has a size distribution of less than 250mu m, thereby obtaining a dry, homogeneous microparticle having at least 80% by weight of metoprolol.