DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH X-PROLYL AMINOPEPTIDASE 2 (XPNPEP2)

摘要

The invention provides a human XPNPEP2 which is associated with the cardiovascular disorders, dermatological disorders, gastrointestinal and liver diseases, metabolic diseases, cancer disorders, neurological disorders, respiratory diseases and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, dermatological disorders, gastrointestinal and liver diseases, metabolic diseases, cancer disorders, neurological disorders, respiratory diseases and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of XPNPEP2 as well as pharmaceutical compositions comprising such compounds.