发明名称 |
METHODS OF SCREENING MOLECULAR LIBRARIES FOR ACTIVE MOLECULES THAT RESTORE THE FUNCTION OF TARGET PROTEINS AND PEPTIDES THAT RESTORE THE FUNCTION OF MUTANT P53 |
摘要 |
The present invention provides a peptide having 2 to 10 amino acids or a derivative thereof which is able to restore wild type function of human p53, for use in therapy; and a method of screening a library of molecules for the ability of members of that library to restore or modify the function of a target protein in an intracellular environment, which method comprises introducing the library into host cells which have a reporter system which allows the identification of those cells in which the function of the target protein has been restored or modified. |
申请公布号 |
WO03072600(A3) |
申请公布日期 |
2005.01.27 |
申请号 |
WO2003GB00291 |
申请日期 |
2003.01.23 |
申请人 |
GARDNER, REBECCA, KATHERINE;EL-GEWELY, MOHAMED, RAAFAT |
发明人 |
EL-GEWELY, MOHAMED, RAAFAT |
分类号 |
A61K38/00;C07K7/06;C12N15/10;C40B30/04;G01N33/68 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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