摘要 |
Antitumor agent which comprises as the principal agent a mixture of organic compounds having amino group and silyl group (reffered to as silamines) and represented by structural formulae with Adriamycin. Use of silamines in the form of a mixture with Adriamycin, which is an anti-cancer agent showing a potent effect but having extremely serious side effects, makes it possible to highly potentiate the anti-cancer properties of Adriamycin. As a result, the dose of Adriamycincan be reduced and thus its side effects can be relatively relieved as compared with the case where it is used alone. <CHEM> Äwherein R1 , R2 , R3 , R4 , R5 , R6 , R7 and R8 represent each hydrogen or C1-10 alkyl, aryl or aralkyl, or the pair of R1 with R2 and that of R5 with R6 may be bonded via alkylene, allylene or aralkylene.Ü |
申请人 |
JAPAN SCIENCE AND TECHNOLOGY CORP., KAWAGUCHI |
发明人 |
KATO, MASAO;KATAOKA, KAZUNORI;NAGASAKI, YUKIO;TAKEZAWA, TSUTOMU |