METHOD FOR PRODUCING IOPAMIDOL

摘要

PROBLEM TO BE SOLVED: To provide a method for efficiently removing an ionic substance from an aqueous solution of iopamidol by using a separation technique by ion exchange.

SOLUTION: The method for producing the iopamidol comprises treating an aqueous solution of iopamidol with a strongly acidic cation exchange resin and then treating the treated aqueous solution with a weakly basic anion exchange resin in which a quaternary amino group in the weakly basic anion exchange resin is adjusted to a salt form and primary to tertiary amino group is adjusted to a free basic form, in a production process for removing the ionic substance from the aqueous solution of iopamidol by using the ion-exchange resin.

COPYRIGHT: (C)2005,JPO&NCIPI