发明名称 |
Monoacylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof |
摘要 |
Betulin and dihydrobetulin acyl derivatives according to the present invention have been found to have potent anti-HIV activity. The compounds of the present invention have Formula I as described herein, or pharmaceutically acceptable salts thereof; wherein R1 is a C2-C20 substituted or unsubstituted carboxyacyl or ester thereof; R2 is hydrogen, halogen, hydroxyl or -OR3, R3 is C2-C20 substituted or unsubstituted carboxyacyl; and R4 is hydrogen or C(C6H5)3; wherein the dashed line represents an optional double bond between C20 and C29.
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申请公布号 |
US2005020548(A1) |
申请公布日期 |
2005.01.27 |
申请号 |
US20040870555 |
申请日期 |
2004.06.18 |
申请人 |
PANACOS PHARMACEUTICALS, INC.;THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL;NIIGATA UNIVERSITY OF PHARMACY AND APPLIED LIFE SCIENCES |
发明人 |
ALLAWAY GRAHAM P.;WILD CARL T.;KASHIWADA YOSHIKI;LEE KUO-HSIUNG |
分类号 |
A61K31/56;A61K39/00;A61K45/06;C07J53/00;(IPC1-7):A61K31/56 |
主分类号 |
A61K31/56 |
代理机构 |
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主权项 |
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地址 |
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