MESALAZINE-BASE PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION WITH SUSTAINED-RELEASE ACTIVE COMPONENT

摘要

FIELD: medicine, pharmacy. ^ SUBSTANCE: invention relates to a pharmaceutical composition that comprises internal lipophilic matrix and external hydrophilic matrix in the mass ratio of lipophilic and hydrophilic matrices from 100:0.5 to 100:20. The internal lipophilic matrix consists of substances with melting point below 90oC and comprises at least partially an active component as globules. As an active component the composition comprises mesalazine - 5-aminosalicylic acid in the concentration up to 95 wt.-%. Lipophilic matrix is dispersed in external hydrophilic matrix. The composition can comprise optionally other excipients. Also, invention describes a method for preparing the composition. Invention provides sustained-release of mesalazine from first phases after administration and more homogenous pattern of release as compared with conventional systems. ^ EFFECT: improved properties of composition. ^ 11 cl, 5 ex