AVIRULENT STRAIN OF MICROORGANISM VIBRIO CHOLERAE KM 169 OF SEROGROUP O139 AS PRODUCER OF CAPSULE ANTIGEN

摘要

FIELD: biotechnology, microbiology. ^ SUBSTANCE: avirulent strain as a producer of capsule antigen is obtained on the base of the natural strain V. cholerae of serogroup O139 by method of step-by-step selection of cells with enhanced production of capsule. Prepared strain forms antigen by 3-4-fold more as compared with other strains of this serogroup. The strain shows high and stable level of capsule antigen production that is one of components of chemical choleraic vaccine against cholera pathogen of serogroup O139. ^ EFFECT: improved preparing method, enhanced yield of antigen. ^ 7 ex