EX VIVO PERFUSION

摘要

A method of removing a target molecule from blood by contacting the blood with an ex vivo perfusion device comprising binding partners for the target molecule is provided. The ex vivo perfusion device preferably comprises one or more immobilized synthebodies as binding partners. Also provided is a method for treating a patient suffering from symptoms associated with an adenoma or other endocrine tumor. The method comprises contacting the blood or a blood component of the patient with an ex vivo perfusion device to which one or more binding partners of a hormone secreted by the tumor are immobilized. The tumor can be, for example, an insulinoma or a parathyroid hormone (PTH) adenoma, and the hormone can be, for example, insulin, PTH, glucagon, VIP, and somatostatin. The binding partner can be, e.g., a synthebody or a part thereof.