发明名称 GAMMA-HYDROXYPROPYLAMMONIUM-5-HYDROXYNICOTINATE ELICITING ANTI-ISCHEMIC, ANTI-ARRHYTHMIC AND HYPOLIPIDEMIC ACTIVITY
摘要 FIELD: organic chemistry, chemical technology, medicine. ^ SUBSTANCE: invention relates to synthesis of new biologically active substance, namely, to gamma-hydroxypropylammonium-5-hydroxynicotinate of the formula (I): , eliciting an anti-ischemic, anti-arrhythmic and hypolipidemic activity. This compound shows low toxicity and absence of cardiodepressive effect. Compound of the formula (I) is prepared by interaction of 5-hydroxynicotinic acid with 3-amino-1-propanol in the presence of a solvent at heating. ^ EFFECT: valuable medicinal properties of compound. ^ 1 cl, 7 tbl, 3 ex
申请公布号 RU2245329(C1) 申请公布日期 2005.01.27
申请号 RU20030127340 申请日期 2003.09.10
申请人 发明人 SERNOV L.N.;SMIRNOV L.D.;KESAREV O.G.;SHAPOSHNIKOVA G.I.
分类号 C07D213/80;A61K31/455;A61P3/00;A61P9/06;A61P9/10 主分类号 C07D213/80
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