发明名称 |
SYSTEM FOR EXTERNAL CONTROL OF ONCOLYTIC VIRUS REPLICATION |
摘要 |
Compositions, methods and a system for external regulation of oncolytic viru s replication are provided. The oncolytic virus contains a cell type-specific transcriptional regulatory element (CT-TRE) and an inducible transactivator regulated transcriptional regulatory element. The virus preferentially replicates in cells that allow a CT-TRE to function. In addition, the concentration of an inducing agent or condition is used to regulate a transactivator regulated transcriptional regulatory element, thereby providi ng at least two levels of control of oncolytic viral replication.
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申请公布号 |
CA2516652(A1) |
申请公布日期 |
2005.01.27 |
申请号 |
CA20042516652 |
申请日期 |
2004.02.24 |
申请人 |
CELL GENESYS, INC. |
发明人 |
HARDING, THOMAS;YU, DE CHAO |
分类号 |
A01N63/00;A01N65/00;A61K31/7088;A61K35/76;A61K48/00;A61P35/00;C12N;C12N1/00;C12N15/34;C12N15/67;C12N15/80;C12N15/86;C12N15/861;(IPC1-7):C12N15/861;A61K31/708 |
主分类号 |
A01N63/00 |
代理机构 |
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