METHOD OF CONSTRUCTING STEREOSTRUCTURE OF PROTEIN HAVING PLURAL NUMBER OF CHAINS

摘要

A method of constructing the stereostructure of a subject protein comprising a plural number of chains having arbitrary amino acid sequences by extending an experiential modeling method of constructing the stereostructure of a subject protein comprising a single chain having an arbitrary amino acid sequence an extended modeling method. In this method, the input forms of the chains in a computer software program are each corrected so as to present a morphology as a dummy single chain correction of sequencial alignment and then the stereostructure is constructed based on the modeling method while assuming that the structure has a plural number of chains in the calculation of the potential formula by the computer software program, thereby constructing the stereostructure of the target protein. Namely, a method of constructing the stereostructure of an arbitrary protein having a plural number of chains, which serves as a key factor in developing drugs or the like, highly accurately and much more efficiently than by conventional methods.