发明名称 |
MEDICAL DEVICE |
摘要 |
The present invention relates to the use of a gene transfer product to reduce hyperplastic connective tissue growth after tissue trauma or implantation of a medical device. The present invention also relates to a medical device with improved biological properties for an at least partial contact with blood, bodily fluids and/or tissues when introduced in a mammalian body, which device comprises a core and a nucleic acid, encoding a product capable of leading to production of extracellular superoxide dismutase present in a biologically compatible medium. Said nucleic acid encodes a translation or transcription product, which is capable of inhibiting hyperplastic connective tissue growth and promoting endothelialisation in vivo at least partially on a synthetic surface of said core. The present invention also relates to a method of producing a medical device according to the invention. |
申请公布号 |
EP1499344(A1) |
申请公布日期 |
2005.01.26 |
申请号 |
EP20030721263 |
申请日期 |
2003.04.30 |
申请人 |
FIT BIOTECH OYJ PLC |
发明人 |
LEPPAENEN, OLLI-PEKKA;YLAE-HERTTUALA, SEPPO;LAUKKANEN, MIKKO;LAHTINEN, MIKA |
分类号 |
A61K38/44;(IPC1-7):A61K38/44;A61F2/00 |
主分类号 |
A61K38/44 |
代理机构 |
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代理人 |
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