Neue gamma-Aryl-alpha,ss-dihalogen-delta?-krotonlaktone,entsprechende ss-Aroyl-ss-halogenakrylsaeuren und Verfahren zur Herstellung derselben

摘要

1,195,922. # - (Substituted benzoyl) - # - haloacrylic acids. SPOFA, UNITED PHARMACEUTICAL WORKS. 16 Feb., 1968 [18 July, 1967], No. 57030/69. Divided out of 1,195,921. Heading C2C. Novel # - (substituted benzoyl) - # -haloacrylic acids having anti-neoplastic effects of the general formula wherein X is a halogen atom, R 1 is a hydrogen atom or a C 1-6 alkoxy group, R 2 is a hydrogen atom or a hydroxy or C 1-6 alkoxy group and R 3 is a C 1-6 alkoxy group, with the proviso that when R 1 and R 2 are hydrogen atoms, R 3 is not a methoxy group, are prepared by hydrolysis of a y - (substituted phenyl) - α,# - dihalo - #α,#- crotonolactone of the general formula