10- (3- CYCLOPROPYLAMINOMETHYL -1-PYRROLIDINYL) PYRIDOBENZOXAZINE CARBOXYLIC ACID DERIVATIVE EFFECTIVE AGAINST RESISTANT BACTERIUM.

摘要

(I) wherein R1 represents methyl, fluoromethyl, methoxymethyl, acetoxymethyl, hydroxymethyl, or methylene; R2 represents hydrogen, C1-3 alkyl, or a pharmaceutically acceptable ester group of a cation and a prodrug; R3 represents hydrogen or halogeno; R4 represents hydrogen, C1-3 alkyl, fluoromethyl, trifluoromethyl, or fluorine; and R5 represents hydrogen or fluorine. It has excellent antibacterial activity against gram-positive bacteria, in particular, resistant bacteria such as MRSA, PRSP, and VRE.