| 摘要 |
<p>An excellent antipruritic drug which functions by a new mechanism. Also provided is a quinazoline derivative represented by the following general formula (1) or a salt thereof: (1) wherein R1 represents hydrogen or alkyl; ring Q represents cyclohexylene or phenylene; A1 and A2 each represents a single bond or alkylene; E represents -NHCO-, etc.; A3 represents a single bond, a divalent (un)saturated aliphatic hydrocarbon group, etc.; R3 represents a noncyclic aliphatic hydrocarbon group, etc.; and R4 and R5 are the same or different and each represents hydrogen, alkyl, etc. The antipruritic drug contains as an active ingredient the derivative or a pharmaceutically acceptable salt of the derivative.</p> |
