发明名称 4-(PHENYL-PIPERIDIN-4-YLIDENE-METHYL)-BENZAMIDE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF PAIN, ANXIETY OR GASTROINTESTINAL DISORDERS
摘要 Compounds of general formula I R1 is selected from any one of phenyl, pyridinyl, pyrrolyl, thienyl, furanyl, imidazolyl, triazolyl, thiazolyl, and pyridine N-oxide; where each R1 phenyl ring and R1 heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C1-C6 alkyl, NO2, CF3, C1-C6 alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the phenyl ring and on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain, anxiety, and functional gastrointestinal disorders.
申请公布号 PL366389(A1) 申请公布日期 2005.01.24
申请号 PL20020366389 申请日期 2002.05.16
申请人 ASTRAZENECA AB 发明人 BROWN WILLIAM;WALPOLE CHRISTOPHER;WEI ZHONGYONG
分类号 C07D401/06;A61K31/445;A61K31/4523;A61K31/4525;A61K31/4535;A61K31/454;A61K31/4545;A61P1/04;A61P1/10;A61P1/12;A61P9/10;A61P9/12;A61P11/00;A61P11/14;A61P13/02;A61P19/08;A61P25/04;A61P25/16;A61P25/18;A61P25/22;A61P25/24;A61P25/30;A61P25/32;A61P25/34;A61P25/36;A61P43/00;C07D211/70;C07D405/06;C07D409/06;C07D417/06 主分类号 C07D401/06
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