发明名称 |
CHITOSAN COMPOSITE CONTAINING HYDROPHOBIC GROUP USEFUL FOR PHARMACEUTICAL CARRIER FOR PROVIDING EXCELLENT BIOCOMPATIBILITY AND BIODEGRADABILITY AND PREPARATION THEREOF |
摘要 |
PURPOSE: Provided is a chitosan composite containing a hydrophobic group, which can encapsulate various hydrophobic pharmaceuticals and therapeutic proteins to give excellent biocompatibility and biodegradability, and thus is useful for pharmaceutical carrier. CONSTITUTION: The chitosan composite containing a hydrophobic group forms a nanosized self-aggregate in aqueous solution. Particularly, an amino group of chitosan is coupled with a carboxyl group of hydrophobic bile acid to form a nanosized self-aggregate. The chitosan is selected from the group consisting of water soluble glycol chitosan, chitosan oligomer and 50%-acetylated chitosan. The hydrophobic bile acid is selected from the group consisting of cholic acid, chenodeoxycholic acid, deoxycholic acid, lithocholic acid, 7-oxo-lithocholic acid and 5-beta-cholanic acid.
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申请公布号 |
KR20050008323(A) |
申请公布日期 |
2005.01.21 |
申请号 |
KR20030048240 |
申请日期 |
2003.07.15 |
申请人 |
JAKWANG CO., LTD.;KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY |
发明人 |
CHUNG, HE SSON;JEONG, SEO YOUNG;KIM, IN SAN;KWON, ICK CHAN;KWON, SEUNG LEE;PARK, JAE HYUNG;SEO, SANG BONG |
分类号 |
C08B37/08;(IPC1-7):C08B37/08 |
主分类号 |
C08B37/08 |
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