ATOPIC DERMATITIS INDUCER

摘要

A purified human secretion fraction, which is an atopic dermatitis inducer binding to human IgE antibody per se and activating mast cells and basophile s, obtained by the following steps: the step of filtering a human secretion, removing the insoluble matters and collecting the filtrate; the step of mixi ng the filtrate with a ConA-affinity carrier and collecting the supernatant; an d the step of separating a component showing a histamine release activity form the supernatant by column chromatography; or an antigen molecule or an antig en determinant contained in this purified fraction. This inducer is efficacious in diagnosing and treating human atopic dermatitis.