发明名称 |
Biodegradable polyurethanes and use thereof |
摘要 |
A biodegradable and biocompatible polyurethane composition synthesized by reacting isocyanate groups of at least one multifunctional isocyanate compound with at least one bioactive agent having at least one reactive group -X which is a hydroxyl group (-OH) or an amine group (-NH2). The polyurethane composition is biodegradable within a living organism to biocompatible degradation products including the bioactive agent. Preferably, the released bioactive agent affects at least one of biological activity or chemical activity in the host organism. A biodegradable polyurethane composition includes hard segments and soft segments. Each of the hard segments is preferably derived from a diurea diol or a diester diol and is preferably biodegradable into biomolecule degradation products or into biomolecule degradation products and a biocompatible diol. Another biodegradable polyurethane composition includes hard segments and soft segments. Each of the hard segments is derived from a diurethane diol and is biodegradable into biomolecule degradation products.
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申请公布号 |
US2005013793(A1) |
申请公布日期 |
2005.01.20 |
申请号 |
US20040759904 |
申请日期 |
2004.01.16 |
申请人 |
BECKMAN ERIC J.;HOLLINGER JEFFREY O.;DOLL BRUCE A.;GUELCHER SCOTT A.;ZHANG JIANYING |
发明人 |
BECKMAN ERIC J.;HOLLINGER JEFFREY O.;DOLL BRUCE A.;GUELCHER SCOTT A.;ZHANG JIANYING |
分类号 |
C08G18/12;C08G18/32;C08G18/34;C08G18/38;C08G18/48;C08G18/64;C08G18/66;C08G18/77;(IPC1-7):A61K31/785;C08G63/48;C08G63/91 |
主分类号 |
C08G18/12 |
代理机构 |
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