LABEL-FREE METHOD FOR CLASSIFICATION AND CHARACTERIZATION OF CELLULAR EVENTS

摘要

This invention incorporates the use of bioimpedance measurements of intact cells to classify and characterize any unique global cellular event such as signal transduction from ligand/receptor interactions, cytotoxicity, apoptosis, tumor cell progression, or stem cell differentiation. Specifically, we have demonstrated that this invention can classify signal transduction pathways from G-protein coupled, tyrosine kinase, and nuclear receptors.