| 摘要 |
The present invention provides compounds having the formula: (I) wherein R1, R', R2, R3, R3~, R4, X1, X2 and X3 are as defined herein, and pharmaceutical compositions thereof. The present invention also provides methods of inhibiting proteases, more specifically aspartyl proteases. In certain embodiments, compounds inhibit BACE (.beta.-site APP-cleaving enzyme), and thus are useful in the treatment or prevention of a disease characterized by .beta.-amyloid deposits in the brain (including, but not limited to, Alzheimer's Disease). The present invention also provides methods for preparing compounds of the invention.
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