| 发明名称 |
METHOD OF TREATING NEURODEGENERATIVE DISEASE |
| 摘要 |
Aspects featured in the invention relate to compositions and methods for inhibiting alpha-synuclein (SNCA) gene expression, such as for the treatment of neurodegenerative disorders. An anti- SNCA agent featured herein that targets the SNCA gene can have been modified to alter distribution in favor of neural cells.
|
| 申请公布号 |
CA2542232(A1) |
申请公布日期 |
2005.01.20 |
| 申请号 |
CA20042542232 |
申请日期 |
2004.06.09 |
| 申请人 |
ALNYLAM PHARMACEUTICALS, INC.;MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH |
发明人 |
MARAGANORE, DEMETRIUS;VORNLOCHER, HANS-PETER;BUMCROT, DAVID;FARRER, MATTHEW J. |
| 分类号 |
C07H21/02;A61K;A61K31/7115;A61K48/00;A61P25/28;C12N15/113;C12Q1/68 |
主分类号 |
C07H21/02 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
