There is provided a stable pharmaceutical formulation comprising (a) an effective amount of levothyroxine sodium, (b) microcrystalline cellulose which has a mean particle size of less than 125µm and is present in an amount of 60 to 85% w/w based upon the total weight of the formulation, and (c) pregelatinised starch present in an amount of 5 to 30% w/w based upon total weight of the formulation. There is also provided a process for the preparation of such a formulation.
申请公布号
WO2005004849(A2)
申请公布日期
2005.01.20
申请号
WO2004EP07667
申请日期
2004.07.08
申请人
GLAXO GROUP LIMITED;KONIECZNA, MALGORZATA;KROHN, HEINER;ROMAN, WANDA;SCHLEHAHN, HENDRIK;STROZYK, MALGORZATA, ANNA
发明人
KONIECZNA, MALGORZATA;KROHN, HEINER;ROMAN, WANDA;SCHLEHAHN, HENDRIK;STROZYK, MALGORZATA, ANNA