EXTENDED RELEASE SYSTEMS FOR MACROLIDE ANTIBIOTICS

摘要

A unit dosage form, such as a tablet or the like for delivering poorly water soluble macrolide antibiotics such as Clarithromycin into the body in an extended release fashion, is designed to release the active ingredient primarily by tablet erosion though the tablet composition does not comprise any dissolution rate controlling agent, a polymer or esters of fatty acids. Such as drug delivery system provides a plasma concentration - time profile suitable for once a day oral transmission.