| 摘要 |
<p>1278681 Peptides M A ONDETTI J PLUSCEC J T SHEEHAN J E JORPES and V MUTT 3 May 1969 [3 May 1968] 20582/69 Heading C2C Novel compounds I in which R is O-sulphate-L-tyrosyl; L-aspartyl- O sulphate - L - tryosyl; protected L-arginyl- L - aspartyl - L - tyrosyl; L - arginyl - L- aspartyl - L - tyrosyl; L - arginyl - L - aspartyl- O sulphate - L - tyrosyl; protected or unprotected L - aspartyl - L - arginyl - L - aspartyl- L - tyrosyl; L - aspartyl - L - arginyl - L- aspartyl - O - sulphate - L - tyrosyl; protected or unprotected L - seryl - L - aspartyl - L- arginyl - L - aspartyl - O - sulphate - L - tyrosyl ; or protected or unprotected isoleucyl-L-seryl- L - aspartyl - L - arginyl - L - aspartyl - O sulphate-L-tyrosyl are prepared by reacting in known manner H - met - gly - trp - met - aspphe-NH 2 with an appropriate amino acid or peptide. The sulphation may be carried out prior to coupling or subsequent thereto by treatment with cone. sulphuric acid in the cold. Intermediates isolated are H-met-gly-trp-metasp-phe-NH 2 prepared by reacting H-gly-trpmet-asp-phe-NH 2 CF 3 COOH with BOC-met-O- (2,4,5-trichlorophenyl) followed by removal of the protecting group in BOC-met-gly-trp-metasp-phe-NH 2 ; and the compounds which are described and claimed in Divisional Specification 1,278,682.</p> |
