发明名称 |
ANTAGONISTS OF FACTOR VIII INTERACTION WITH LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN |
摘要 |
<p>The present invention concerns the use of peptides derived from and antibodies generated against Factor VIII and the inhibition of Factor VIII interaction with LRP. Furthermore, the present invention concerns a method to inhibit LRP interaction with Factor VIII as well as a method to decrease Factor VIII degradation and/or prolong Factor VIII half-life in a biological fluid and/or a method to treat patients suffering from a blood coagulation disorder, especially Haemophilia A. The present invention also concerns a pharmaceutical composition useful for the decrease of Factor VIII degradation in a biological fluid, the inhibition of Factor VIII interaction with LRP, and/or the prolongation of Factor VIII half-life in a biological fluid for treatment of a blood coagulation disorder, especially Haemophilia A.</p> |
申请公布号 |
EP1497330(A2) |
申请公布日期 |
2005.01.19 |
申请号 |
EP20030725109 |
申请日期 |
2003.04.28 |
申请人 |
BAXTER INTERNATIONAL INC.;BAXTER HEALTHCARE S.A.;STICHTING SANQUIN BLOEDVOORZIENING |
发明人 |
MERTENS, KOENRAAD;BOVENSCHEN, AREND, NIELS;VOORBERG, JAN;RIEGER, MANFRED;SCHEIFLINGER, FRIEDRICH |
分类号 |
C07K16/36;C12N15/09;A61K38/00;A61K39/00;A61K39/395;A61P7/02;A61P7/04;A61P41/00;A61P43/00;C07K14/755;(IPC1-7):C07K14/755;A61K38/37 |
主分类号 |
C07K16/36 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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