| 摘要 |
<p>An anti-parasitic pour-on composition for treating animals comprises a salicylanilide, especially closantel, alone or together with at least one other anti-parasitic compound of the avermectin or milbemycin type and offers enhanced bioavailability of the salicylanilide by provision of a delivery system comprising at least 20%(v/v) of one or more alcohols. The composition optionally includes a polymeric moiety selected from polyvinylpyrrolidone (PVP), polyoxypropylene/polyoxyethylene block copolymers (poloxamer), and polyethylene glycols (PEG), thereby improving the bioavailability of e.g. closantel (as assessed with respect to blood plasma levels of closantel).</p> |
