发明名称 |
Gene therapy approaches to supply apolipoprotein A-I agonists and their use to treat dyslipidemic disorders |
摘要 |
The invention relates to genetic approaches to supply nucleotide sequences encoding modified forms of the native forms of apolipoprotein A-I (ApoA-I): mature ApoA-I, preproApoA-I and proApoA-I; including native ApoA-I modified to contain ApoA-I agonists, peptides which mimic the activity of ApoA-I; ApoA-I superagonists, peptides which exceed the activity of native ApoA-I; and modified native ApoA-I having one or more amphipathic helices replaced by the nucleotide sequences of one or more ApoA-I agonists; for the treatment of disorders associated with dyslipoproteinemia, including cardiovascular disease, atherosclerosis, restenosis, hyperlipidemia, and other disorders such as septic shock.
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申请公布号 |
US6844327(B2) |
申请公布日期 |
2005.01.18 |
申请号 |
US20020283599 |
申请日期 |
2002.10.29 |
申请人 |
DASSEUX JEAN-LOUIS;SEKUL RENATE;BUETTNER KLAUS;CORNUT ISABELLE;METZ GUENTHER;DUFOURCQ JEAN |
发明人 |
DASSEUX JEAN-LOUIS;SEKUL RENATE;BUETTNER KLAUS;CORNUT ISABELLE;METZ GUENTHER;DUFOURCQ JEAN |
分类号 |
C12N15/09;A61K38/00;A61K38/16;A61K48/00;A61P3/00;A61P3/06;A61P9/00;A61P9/10;A61P31/04;A61P43/00;C07H21/00;C07K7/06;C07K7/08;C07K14/00;C07K14/47;C07K14/775;C12N5/10;(IPC1-7):A01N43/04;C07H21/02;C12P21/06;C12N1/20;C12N15/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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