| 摘要 |
A procedure for preparing 6-O-alkyl erythromycin compounds having formula (I ), wherein R1 is a loweralkyl group, R2 and R3 are independently hydrogen or a hydroxy-protecting group, except that R2 and R3 may not both be hydrogen simultaneously; Y is oxygen or a specifically substituted oxime; and Z is hydrogen, hydroxy or protected- hydroxy; by reaction of the compound wherein R1 is hydrogen with an alkylating reagent, in the presence of a strong alkali metal base an d also in the presence of a weak organic amine base, in a suitable stirred or agitated polar aprotic solvent, or a mixture of such polar aproti c solvents maintained at a reaction temperature and for a period of time sufficient to effect alkylation.
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