| 发明名称 |
Peptidase-cleavable, targeted antineoplastic drugs and their therapeutic use |
| 摘要 |
This invention is directed to antineoplastic agents conjugated to enzyme-cleavable peptides comprising the amino acid recognition sequence of a membrane-bound and/or cell-secreted peptidase, and to the use of such conjugated compounds as chemotherapeutic agents in the targeted treatment of cancers.
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| 申请公布号 |
US6844318(B2) |
申请公布日期 |
2005.01.18 |
| 申请号 |
US20010808832 |
申请日期 |
2001.03.15 |
| 申请人 |
BRISTOL MYERS SQUIBB PHARMA COMPANY |
发明人 |
COPELAND ROBERT A.;ALBRIGHT CHARLES F.;COMBS ANDREW P.;DOWLING RANDINE L.;GRACIANI NILSA R.;HAN WEI;HIGLEY C. ANNE;HUANG PEARL S.;YUE EDDY W.;DIMEO SUSAN V. |
| 分类号 |
A61K31/704;A61K38/00;A61K47/48;A61P35/00;A61P35/02;C07K5/02;C07K5/04;C07K5/117;C07K7/06;(IPC1-7):A61K38/07;A61K38/08;A61K38/14 |
主分类号 |
A61K31/704 |
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