| 摘要 |
This invention relates to a phosphodiesterase IV inhibitor containing as an active ingredient a pyridylacrylamide derivative represented by the following formula (I): <CHEM> (wherein Ar<1> represents substituted or unsubstituted pyridyl; Ar<2> represents phenyl substituted by alkoxy, etc.; R<1> represents hydrogen, alkyl, or aryl; R<2> represents hydrogen, alkyl, cyano, or alkoxycarbonyl; R<3> represents hydrogen or optionally substituted alkyl; X represents oxygen or sulfur; A and B are the same or different and each independently represents hydrogen, hydroxyl, alkoxy, or alkylthio, or A and B together represent oxo, thioxo, etc., or A may be hydroxyl and B may be 1-alkylimidazol-2-yl; and n is an integer from 1 to 3) or a pharmaceutically acceptable salt thereof.
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