发明名称 LIQUID PREPARATION COMPRISING CAMPTOTHECIN DERIVATIVE AND PHARMACEUTICAL COMPOSITION PRODUCED BY FREEZE-DRYING
摘要 The present invention relates to a stable liquid preparation comprising a camptothecin derivative which is prepared by binding a compound of the formula [I]:wherein R1 is a substituted or unsubstituied lower alkyl group, ?1 is a group of the formula: -NHR2 (R2 is a hydrogen atom or a lower alkyl group) or a hydroxy group and Alk is a straight or branched chain alkylene group optionally interruptedby an oxygen atom, and a polysaccharide having carboxyl groups via an amino acid or a peptide, or a pharmaceutically acceptable sail thereof, which is adjusted to pH 5-8, or a stable pharmaceutical composition produced by lyophilizing said liquid preparation.
申请公布号 UA77295(C2) 申请公布日期 2005.01.17
申请号 UA20041109367 申请日期 2003.04.15
申请人 TANABE SEIYAKU CO., LTD. 发明人
分类号 A61K47/48;A61K9/00;A61K9/08;A61K9/19;A61K47/02;A61K47/12;A61K47/26;A61K47/36;C07D491/147 主分类号 A61K47/48
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