发明名称 |
METHODE ZUR BEHANDLUNG VON TUMOREN WELCHE DEN VASKULÄREN ENDOTHELIALEN WACHSTUMSFAKTOR D EXPRIMIEREN |
摘要 |
A method for treating and alleviating melanomas and various cancers characterized by the expression of VEGF-D by the tumor, the method comprising screening to find an organism with tumor cells expressing VEGF-D and administering an effective amount of a VEGF-D antagonist to prevent binding of VEGF-D; methods for screening for neoplastic diseases, where detection of VEGF-D on or in cells such as tumor cells, blood vessel endothelial cells, lymph vessel endothelial cells, and/or cells with potential neoplastic growth indicates neoplastic disease; a method for promoting and maintaining vascularization of normal tissue in an organism by administering VEGF-D or a fragment or analog thereof; methods for screening tumors for metastatic risk where expression of VEFG-D by the tumor indicates metastatic risk; and methods to detect micro-metastasis of neoplastic disease where detection of VEGF-D on or in a tissue sample indicates metastasis of neoplastic disease. |
申请公布号 |
AT284701(T) |
申请公布日期 |
2005.01.15 |
申请号 |
AT20010913267T |
申请日期 |
2001.03.02 |
申请人 |
LUDWIG INSTITUTE FOR CANCER RESEARCH |
发明人 |
ACHEN, MARC, LUDWIG;STACKER STEVEN LUDWIG;STACKER, STEVEN, |
分类号 |
C12Q1/02;A61K38/19;A61K38/22;A61K39/395;A61K45/00;A61P9/00;A61P35/00;C07K16/22;C07K16/24;G01N33/574;(IPC1-7):A61K38/02 |
主分类号 |
C12Q1/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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