INHIBITORS OF CORONAVIRUS

摘要

The present invention relates to inhibitors of coronaviruses including sever e acute respiratory syndrome (SARS); methods of identifying inhibitors of coronaviruses; methods and compositions useful for therapy (treatment, or prevention) of coronavirus infections. The coronavirus inhibitors target different regions of the coronavirus Spike protein to inhibit coronavirus replication. In particular embodiments, the inhibitors include Five-Helix proteins, HR2 peptides, HR1 peptides, HR1 chimeric peptides. The present invention also features retro-inverso analogue of the coronavirus inhibitors , coronavirus inhibitors containing one or more tryptophan analogs, and / or o ne or more lactam bridges.