发明名称 |
Conjugates comprising human IL-18 and substitution mutants thereof |
摘要 |
Human interleukin-18 (IL-18) polypeptides and substitution mutants thereof were conjugated to water-soluble polymers at specific sites on the human IL-18 protein. These conjugated human IL-18 and substitution mutants thereof retain biological activity. These conjugated cytokines demonstrate enhanced and unexpected biological properties when compared to the corresponding unconjugated cytokines.
|
申请公布号 |
US2005008615(A1) |
申请公布日期 |
2005.01.13 |
申请号 |
US20040823964 |
申请日期 |
2004.04.14 |
申请人 |
BAM NARENDRA;BONGERS JACOB;KIRKPATRICK ROBERT B.;JANSON CHERYL A.;JONAK ZDENKA;QIU XIANYANG;YEH PING;JOHANSON KYUNG |
发明人 |
BAM NARENDRA;BONGERS JACOB;KIRKPATRICK ROBERT B.;JANSON CHERYL A.;JONAK ZDENKA;QIU XIANYANG;YEH PING;JOHANSON KYUNG |
分类号 |
A61K;A61K38/00;A61K38/20;C07K14/54;(IPC1-7):C07K14/54 |
主分类号 |
A61K |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|