摘要 |
This invention relates to novel anthraquinone compounds useful in the treatment of allergic, inflammatory conditions, antioxidant, tumor condition, stem cell application, tissue engineering, applied in treating age-associate tissue degeneration, reverse organ failure in chronic high-turnover disease and therapeutic compositions containing such compounds. The compounds of the present invention are 1,4-, 1,5- and 1,8-difunctionalized anthraquinones or analogs thereof. According to the practice of the invention, there are provided bis-symmetrical substituted anthraquinone compounds according to formula I: wherein R1, R2, R3 and R4 present a straight, aminoalkylamino side chains or branched chain alkyl group having 1 to 6 carbons which may be substituted with one or more groups of R5, or R1, R2, R3 and R4 present phenyl or benzyl which may be substituted with one or two groups of R6; wherein R5 is selected from the group consisting of halogen, -RNH2, -RNH2R, -ROH, -NO2, -OCH3, -OCH2CH3, and -OCH2CH2CH3; and wherein R6 is selected from the group consisting of a straight or branched chain alkyl group having 1 to 4 carbons, halogen, -RNH2, -RNH2R, -ROH, -NO2, -OCH3, -OCH2CH3, -OCH2CH2CH3, -CH2Br, -CH2Cl, -CH2OH, -C(CH3)3, -(CH2)20H, -(CH2)3OH, -(CH2)4OH, -CH2NH2, -(CH2)2NH2, -(CH2)3NH2, -(CH2)4NH2, -(CH2)5NH2, -CH2N(CH3)2, -(CH2)2N(CH3)2, -(CH2)2NH(CH2)2OH, -(CH2</highlig
|