ENZYMATIC RESOLUTION OF (±) METHYL TRANS-3-PHENYL GLYCIDATE

摘要

The present invention relates to a method for preparing (2S,3R) alkyl trans-3-phenylglycidate or (2R,3S) methyl trans-3-phenylglycidate comprising:- enzymatic resolution by trans-esterification of ± methyl trans-3-phenylglycidate with enantiomeric excess using lipozyme in the presence of a transesterification agent and an organic solvent to obtain (2R,3S) methyl trans-3-phenylglycidate and (2S,3R) alkyl trans-3-phenylglycidate and- isolating (2S,3R) alkyl trans-3-phenylglycidate from (2R,3S) methyl trans-3-phenylglycidate